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Heredity

 

Heredity Intra-abdominal Diet Lung

Some people are born with a weak lower esophageal sphincter or LES. This often runs in families. It is not uncommon to find reflux in two or more generations, but it can skip a generation and manifest itself in a first and third generation. It can be seen in one child or in siblings. If it severely affects one child, but spares the siblings, the affected child often shows signs of decreased physical growth. Reflux disease is often seen in cerebral palsy children.

Babies with GERDS often vomit a lot. They grow into children who have often been labeled in the past as having a nervous stomach, or the parents are simply told that they are trying to avoid going to school. These children may continue to have a lifetime of heartburn and suffering. In the past we only commiserated with their suffering, but in view of the above information of the eight fold increase in adenocarcinoma of the esophagus and two fold increase in cancer of the stomach, these children must now be afforded the treatment that will cure the reflux not just control the symptoms.

A gene has been mapped for severe gastroesophageal reflux to chromosome 13q14. Other genes may be linked to less severe gastroesophageal reflux, this hereditary transmission is by autosomal dominant inheritance.

 

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